If you include non-humans, then Stan from Dog with a Blog is the second adult protagonist, albeit a dog.
*Raven’s Home stars Raven-Symoné as an adult in-canon, but I’m reluctant to include it since it is a spin-off of Raven’s teenage character in That’s So Raven.
If you accept movies and works where there is a shared protagonist role, then you could count Freaky Friday and I assume its spin-offs.
Apparently there was almost a show about Arwen from Suite Life of Zack and Cody but Disney passed on it in favour of Wizards of Waverly Place
Acceptable decision
Actually, there are probably quite a few movies. Honey, I Shrunk the Kids comes to mind.
There was an Emperor’s New Groove show and Kuzco is an adult
Buzz Lightyear of Star Command
The Emperor’s New Groove is such a great movie. I actually mentioned watching it to my family a few days ago.
But yeah, cartoon characters in general are a bit of a toss-up, and their ages are hardly ever quite clear. I thought of all the Disney princess movies and decided to specify “live-action” in the title.
If you couldn’t tell, I was like a mid-gen Disney Channel viewer.
