If you include non-humans, then Stan from Dog with a Blog is the second adult protagonist, albeit a dog.
*Raven’s Home stars Raven-Symoné as an adult in-canon, but I’m reluctant to include it since it is a spin-off of Raven’s teenage character in That’s So Raven.
If you accept movies and works where there is a shared protagonist role, then you could count Freaky Friday and I assume its spin-offs.
Actually, there are probably quite a few movies. Honey, I Shrunk the Kids comes to mind.
Apparently there was almost a show about Arwen from Suite Life of Zack and Cody but Disney passed on it in favour of Wizards of Waverly Place
Acceptable decision
There was an Emperor’s New Groove show and Kuzco is an adult
Buzz Lightyear of Star Command
The Emperor’s New Groove is such a great movie. I actually mentioned watching it to my family a few days ago.
But yeah, cartoon characters in general are a bit of a toss-up, and their ages are hardly ever quite clear. I thought of all the Disney princess movies and decided to specify “live-action” in the title.
If you couldn’t tell, I was like a mid-gen Disney Channel viewer.
