I feel that. I hope you meet people that truly care about you, if you haven’t already.

Infrared guidance does not count towards optimal experience.

The efficiency of phenylalanine (Phe) utilization for milk protein synthesis in dairy cows is limited, and its uptake and metabolic mechanisms in the mammary tissue remaining unclear. This study investigated the effects of Phe availability (0.07, 0.14, 0.28, and 0.56 mM) on amino acid metabolism and casein synthesis in bovine mammary epithelial cells (BMECs) cultured for 24 h. Results showed that αS1-casein, β-casein, and κ-casein expression peaked at 0.14 mM Phe (p < 0.05). At this optimal concentration, amino acid transporters (SLC7A5, SLC7A8, and SLC38A2) were upregulated, corresponding with enhanced uptake of Met, Ile, His, and Arg (p < 0.05). The mammalian target of rapamycin (mTOR) signaling pathway was activated as evidenced by increased phosphorylation of P70 S6 kinase (P70S6K) and mTOR (p < 0.05), while the general control nonderepressible 2 (GCN2) pathway was suppressed through reduced eukaryotic initiation factor 2α (eIF2α) phosphorylation (p < 0.05). As Phe concentration increased, its net uptake increased linearly (Plinear < 0.05) while uptake efficiency decreased linearly (Plinear < 0.05). High Phe concentration (0.56 mM) inhibited amino acid transporter expression and reduced uptake of Leu, Pro, and Tyr (p < 0.05). Additionally, Phe-to-Tyr conversion was dynamically regulated, with phenylalanine hydroxylase (PAH) activity inhibited at 0.07 mM Phe (p < 0.05) but enhanced at higher concentrations, concurrent with reduced exogenous Tyr uptake (p < 0.05). These findings show that casein synthesis in BMECs is optimal at 0.14 mM Phe, coinciding with enhanced expression of amino acid transporters and activation of protein synthesis pathways. In contrast, higher Phe concentrations (0.56 mM) are associated with reduced amino acid utilization efficiency. These observations suggest potential mechanisms by which Phe concentration may regulate milk protein synthesis in dairy cows.

Xing Y, Luo Y, Sun M, Yang J, Lin S, Mu X, Niu X, Li D and Liu Y (2025) Phenylalanine modulates casein synthesis in bovine mammary epithelial cells by influencing amino acid transport and protein synthesis pathways. Front. Nutr. 12:1598191. doi: 10.3389/fnut.2025.1598191

The aliens also want you to take your meds.

Does Agott have a redemption arc or are we just going to hate her for the whole series? 😤

The US can kiss my shiny, metal ass.

I’m a bit miffed Agott was let off the hook for almost killing Coco.

I kinda thought so, I was referring to the opp.

>Posts a meme about being ungovernable.  
>Self censors to appease the tech bro corporates

I like it when that happens because the hairs scratch itches way back there.

I prefer the reproductive cycle of hyenas and kangaroos.

and leaving no room for semantic arguments or arguments in general.

Excuse me?

To make it accurate you have to put the owner in the trunk.

Allbirds Nobirds

Them: “I’M GOING TO CRUSH YOU.”

Me: “😳”

Reminds me of how factory ships in The Culture series by Iain M. Banks would operate in full vacuum if they had to to do away with air resistance.

Good boy, Chewbacca.